Considerations for OCV use with Pregnant Women
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چکیده
Cholera in pregnant women has been linked to higher rates of miscarriages and stillbirths. When used effectively, oral cholera vaccines (OCVs) can prevent or control cholera outbreaks and manage endemic cholera. For this reason, the World Health Organization (WHO) listed pregnant women in its 2010 position paper on cholera vaccines as a group that is “especially vulnerable to severe disease and for which the vaccines are not contraindicated” and that therefore may also be targeted for cholera vaccination.1 Pregnant women have been excluded from clinical trials of OCVs resulting in a lack of controlled data on their safety during pregnancy. As a result, the package insert of Shanchol, a killed whole-cell oral vaccine now being used in cholera-affected countries, states that the vaccine is not recommended for use in pregnancy, except under certain circumstances (see box). Interestingly, the package insert for Dukoral − a similar killed whole-cell oral vaccine that includes a component of the cholera toxin and is used mainly by travelers – states that the vaccine “may be administered during pregnancy and to lactating women.” 2
منابع مشابه
Safety of the oral cholera vaccine in pregnancy: Retrospective findings from a subgroup following mass vaccination campaign in Dhaka, Bangladesh☆
BACKGROUND Pregnant women are vulnerable to complications of cholera. Killed oral cholera vaccines (OCV) are not recommended for pregnant women though there is no evidence of harmful effects during pregnancy. We evaluated the effect of a killed OCV, Shanchol™, on pregnancy outcomes during an effectiveness trial of the vaccine in urban Bangladesh. METHODOLOGY Individuals ⩾1year were invited to...
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